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Article

Real-Time Reverse Transcription-PCR Assay for Future Management of ERBB2-based Clinical Applications

1 Aug 1999

Abstract excerpt

BACKGROUND: Gene amplification/overexpression of ERBB2 (HER2, neu) is a major event in human breast tumorigenesis. ERBB2-based therapeutic agents and ERBB2-specific gene therapy are under development. These new perspectives call for a sensitive and accurate method to screen breast cancer patients for ERBB2 alterations. METHODS: We have developed and validated a real-time quantitative reverse transcription...

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PMID: 10430778
DOI: 10.1093/clinchem/45.8.1148

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