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Article

Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.

PloS one - 1 Jan 2014

D'Alton Simon, Altshuler Marcelle, Cannon Ashley, Dickson Dennis W, Petrucelli Leonard, Lewis Jada

Abstract excerpt

The majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis are pathologically defined by the cleavage, cytoplasmic redistribution and aggregation of TAR DNA binding protein of 43 kDa (TDP-43). To examine the contribution of these potentially toxic mechanisms in vivo, we generated transgenic mice expressing human TDP-43 containing the familial amyotrophic lateral sclerosis-linked...

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Identifiers

PMID: 24466128
DOI: 10.1371/journal.pone.0086513
PMCID: PMC3899264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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