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Article

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Molecular neurodegeneration - 26 Oct 2011

Xu Ya-Fei, Zhang Yong-Jie, Lin Wen-Lang, Cao Xiangkun, Stetler Caroline, Dickson Dennis W, Lewis Jada, Petrucelli Leonard

Abstract excerpt

BACKGROUND: Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). Researchers have identified 44 mutations in the TARDBP gene that encode TDP-43 as causative for cases of...

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Identifiers

PMID: 22029574
DOI: 10.1186/1750-1326-6-73
PMCID: PMC3216869

Genes

TARDBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.PMID 22029574Read ↗

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