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Article

Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

26 Apr 2012

Abstract excerpt

Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43 plays a critical, although undefined role in development. In the current report, we generated transgenic mice that conditionally express wild-type human TDP-43...

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PMID: 22539017
DOI: 10.1007/s00401-012-0979-3

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