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Article

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009

Wegorzewska Iga, Bell Shaughn, Cairns Nigel J, Miller Timothy M, Baloh Robert H

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases that show considerable clinical and pathologic overlap, with no effective treatments available. Mutations in the RNA binding protein TDP-43 were recently identified in patients with fam...

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Identifiers

PMID: 19833869
DOI: 10.1073/pnas.0908767106
PMCID: PMC2762420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19833869-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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