Article
Synergistic effects of high blood cholesterol and hypertension on leukocyte and platelet recruitment in the cerebral microcirculation.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2014
Rodrigues Stephen F, Almeida-Paula Lidiana D, Granger Daniel N
Abstract excerpt
Hypertension or hypercholesterolemia can induce a proinflammatory and prothrombogenic phenotype in the microcirculation of the brain; however, less is known about how the combination of these risk factors affects the vasculature. We recently reported that a moderate (60%) increase in plasma cholesterol blunts the recruitment of leukocytes and platelets in the cerebral microvessels elicited by hypertension. In...
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