Article
Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide.
Free radical biology & medicine - 15 Oct 2002
Stokes Karen Y, Cooper Dianne, Tailor Anitaben, Granger D Neil
Abstract excerpt
Relatively brief periods (days) of hypercholesterolemia can exert profound effects on endothelium-dependent functions of the microcirculation, including dilation of arterioles, fluid filtration across capillaries, and regulation of leukocyte recruitment in postcapillary venules. Hypercholesterolemia appears to convert the normal anti-inflammatory phenotype of the microcirculation to a proinflammatory phenotype....
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