Article
Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage.
Stroke - 1 Dec 2007
Chaichana Kaisorn L, Levy Andrew P, Miller-Lotan Rachel, Shakur Sophia, Tamargo Rafael J
Abstract excerpt
BACKGROUND AND PURPOSE: Chronic cerebral arterial vasospasm is the leading cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Not all cases of SAH, however, develop chronic vasospasm. Inflammation, specifically leukocyte-endothelial cell interactions, appears to be critical in vasospasm development. Haptoglobin (Hp) is a serum protein that limits the extent of inflammation after a...
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