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Article

In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2008

Takahashi Mayumi, Hiyama Yaeko, Yokoyama Masayoshi, Yu Shuiqing, Hu Yunying, Melford Kristan, Bensadoun André, Goldberg Ira J

Abstract excerpt

OBJECTIVE: Although epidemiologic data suggest that hypertriglyceridemia and elevated plasma levels of fatty acids are toxic to arteries, in vitro correlates have been inconsistent. To investigate whether increased endothelial cell expression of lipoprotein lipase (LpL), the primary enzyme creating free fatty acids from circulating triglycerides (TG), affects vascular function, we created transgenic mice that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lipoproteins, VLDL

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Source

Identifiers

PMID: 18258818
DOI: 10.1161/ATVBAHA.107.153239

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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