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Article

Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo.

Heart and vessels - 1 May 2016

Heim Christian, Gebhardt Julia, Ramsperger-Gleixner Martina, Jacobi Johannes, Weyand Michael, Ensminger Stephan M

Abstract excerpt

The anti-platelet drug clopidogrel has been shown to modulate adhesion molecule and cytokine expression, both playing an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the impact of clopidogrel on the development and progression of atherosclerosis. ApoE(-/-) mice fed an atherogenic diet (cholesterol: 1 %) for 6 months received a daily dose of clopidogrel (1 mg/kg)...

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Identifiers

PMID: 26062773
DOI: 10.1007/s00380-015-0696-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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