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Article

iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls.

Trends in molecular medicine - 1 Feb 2014

Prilutsky Daria, Palmer Nathan P, Smedemark-Margulies Niklas, Schlaeger Thorsten M, Margulies David M, Kohane Isaac S

Abstract excerpt

The elucidation of disease etiologies and establishment of robust, scalable, high-throughput screening assays for autism spectrum disorders (ASDs) have been impeded by both inaccessibility of disease-relevant neuronal tissue and the genetic heterogeneity of the disorder. Neuronal cells derived from induced pluripotent stem cells (iPSCs) from autism patients may circumvent these obstacles and serve as relevant...

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Identifiers

PMID: 24374161
DOI: 10.1016/j.molmed.2013.11.004
PMCID: PMC4117413

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