Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties.

doi:10.1096/fj.13-239012

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Article

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014

Faleri Agnese, Santini Laura, Brier Sébastien, Pansegrau Werner, Lo Surdo Paola, Scarselli Maria, Buricchi Francesca, Volpini Gianfranco, Genovese Alessia, van der Veen Stijn, Lea Susan, Tang Christoph M, Savino Silvana, Pizza Mariagrazia, Finco Oretta, Norais Nathalie, Masignani Vega

Abstract excerpt

Factor H binding protein (fHbp) is one of the main antigens of the 4-component meningococcus B (4CMenB) multicomponent vaccine against disease caused by serogroup B Neisseria meningitidis (MenB). fHbp binds the complement down-regulating protein human factor H (hfH), thus resulting in immune evasion. fHbp exists in 3 variant groups with limited cross-protective responses. Previous studies have described the...

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PMID: 24371123
DOI: 10.1096/fj.13-239012

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