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Nonfunctional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine Candidates

31 Dec 2013

Abstract excerpt

Neisseria meningitidis is a human-specific pathogen and leading cause of meningitis and septicemia. Factor H binding protein (fHbp), a virulence factor which protects N. meningitidis from innate immunity by binding the human complement regulator factor H (fH) with high affinity, is also a key antigen in vaccines being developed to prevent meningococcal disease. fHbp can be divided into three variant groups (V1,...

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PMID: 24379280
DOI: 10.1128/iai.01183-13

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