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Transmission and Long-Term Stability of Compensated CD8 Escape Mutations

18 Dec 2008

Abstract excerpt

Human immunodeficiency virus effectively evades CD8(+) T-cell responses through the development of CD8 escape mutations. Recent reports documenting reversion of transmitted mutations and the impact of specific escape mutations upon viral replication suggest that complex forces limit the accumulation of CD8 escape mutations at the population level. However, the presence of compensatory mutations capable of...

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Identifiers

PMID: 19091871
DOI: 10.1128/jvi.01108-08

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