Vaccination and timing influence SIV immune escape viral dynamics in vivo.

doi:10.1371/journal.ppat.0040012

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Article

Vaccination and timing influence SIV immune escape viral dynamics in vivo.

PLoS pathogens - 1 Jan 2008

Loh Liyen, Petravic Janka, Batten C Jane, Davenport Miles P, Kent Stephen J

Abstract excerpt

CD8+ cytotoxic T lymphocytes (CTL) can be effective at controlling HIV-1 in humans and SIV in macaques, but their utility is partly offset by mutational escape. The kinetics of CTL escape and reversion of escape mutant viruses upon transmission to MHC-mismatched hosts can help us understand CTL-mediated viral control and the fitness cost extracted by immune escape mutation. Traditional methods for following CTL...

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Identifiers

PMID: 18225952
DOI: 10.1371/journal.ppat.0040012
PMCID: PMC2323283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.