Article
Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.
PLoS pathogens - 1 Apr 2009
Loh Liyen, Reece Jeanette C, Fernandez Caroline S, Alcantara Sheilajen, Center Robert, Howard Jane, Purcell Damian F J, Balamurali Mehala, Petravic Janka, Davenport Miles P, Kent Stephen J
Abstract excerpt
Escape mutant (EM) virus that evades CD8+ T cell recognition is frequently observed following infection with HIV-1 or SIV. This EM virus is often less replicatively "fit" compared to wild-type (WT) virus, as demonstrated by reversion to WT upon transmission of HIV to a naïve host and the association of EM virus with lower viral load in vivo in HIV-1 infection. The rate and timing of reversion is, however, highly...
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