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Article

Genotype-dependent molecular evolution of sheep bovine spongiform encephalopathy (BSE) prions in vitro affects their zoonotic potential.

The Journal of biological chemistry - 19 Sept 2014

Krejciova Zuzana, Barria Marcelo A, Jones Michael, Ironside James W, Jeffrey Martin, González Lorenzo, Head Mark W

Abstract excerpt

Prion diseases are rare fatal neurological conditions of humans and animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic form of the cattle disease bovine spongiform encephalopathy (BSE). What makes one animal prion disease zoonotic and others not is poorly understood, but it appears to involve compatibility between the prion strain and the host prion protein sequence. Concerns have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25100723
DOI: 10.1074/jbc.M114.582965
PMCID: PMC4176218

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