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Article

PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes.

Journal of cellular biochemistry - 1 Jan 2019

Negoita Florentina, Blomdahl Julia, Wasserstrom Sebastian, Winberg Martin E, Osmark Peter, Larsson Sara, Stenkula Karin G, Ekstedt Mattias, Kechagias Stergios, Holm Cecilia, Jones Helena A

Abstract excerpt

The mechanism of how patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant M148 is associated with increased risk of development of hepatic steatosis is still debated. Here, we propose a novel role of PNPLA3 as a key player during autophagosome formation in the process of lipophagy. A human hepatocyte cell line, HepG2 cells, expressing recombinant I148 or 148M, was used to study lipophagy under...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30171718
DOI: 10.1002/jcb.27378

Genes

PNPLA3
LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes.PMID 30171718Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamicsSemantic proximity Read ↗

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read ↗

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.Semantic proximity Read ↗

The fatty liver disease–causing protein PNPLA3-I148M alters lipid droplet–Golgi dynamicsSemantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective.Semantic proximity Read ↗

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance PathwaysSemantic proximity Read ↗

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A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease.Semantic proximity Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.Semantic proximity Read ↗

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