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Article

The signalling profile of recombinant human orexin-2 receptor.

Cellular signalling - 1 Sept 2008

Tang Jiyou, Chen Jing, Ramanjaneya Manjunath, Punn Anu, Conner Alex C, Randeva Harpal S

Abstract excerpt

Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. In many tissues, orexins activate extracellular signal-regulated kinase (ERK(1/2)) and p38 mitogen-activated protein kinase (MAPK); however, the mechanism by which OX2R alone mediates MAPK activation is not understood. This study describes the...

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Identifiers

PMID: 18599270
DOI: 10.1016/j.cellsig.2008.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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