Article
Multi-component signaling complexes of the delta-opioid receptor with STAT5B and G proteins.
Neuropharmacology - 1 Sept 2010
Georganta Eirini-Maria, Agalou Adamantia, Georgoussi Zafiroula
Abstract excerpt
Besides mediating opioid responses in the nervous system and the peripheral tissues, opioid receptors are implicated in signaling mechanisms shared by cytokine receptors. Recent observations have shown that the Signal Transducer and Activator of Transcription 5A (STAT5A) interacts with the mu-opioid receptor (mu-OR) and is phosphorylated upon mu-OR stimulation (Mazarakou and Georgoussi, 2005). In the present...
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