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Article

Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists.

European journal of pharmacology - 30 Sept 2011

Tran Da-Thao, Bonaventure Pascal, Hack Michael, Mirzadegan Taraneh, Dvorak Curt, Letavic Michael, Carruthers Nicholas, Lovenberg Timothy, Sutton Steven W

Abstract excerpt

Orexin receptor antagonists are being investigated as therapeutic agents for insomnia and addictive disorders. In this study the interactions between the orexin receptors (orexin 1 receptor and orexin 2 receptor), orexin peptides, and small molecule orexin antagonists were explored. To study thes...

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Source

Identifiers

PMID: 21679703
DOI: 10.1016/j.ejphar.2011.05.074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21679703-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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