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Article

C-terminus of OX2R significantly affects downstream signaling pathways.

Molecular medicine reports - 1 Jul 2017

Wang Chunmei, Xu Chao, Liu Minghui, Pan Yanyou, Bai Bo, Chen Jing

Abstract excerpt

The human orexin 2 receptor (OX2R) is a G-protein‑coupled receptor (GPCR) that has been implicated in a number of diverse physiological functions. Recent studies have identified a number of functions of the C‑termini of GPCRs. However, the importance of the OX2R C‑terminus in regulating signaling and surface expression remains unclear. In the present study, the function of the OX2R C‑terminus was investigated...

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Identifiers

PMID: 28487995
DOI: 10.3892/mmr.2017.6557
PMCID: PMC5482145

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