Article
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors.
The Journal of biological chemistry - 11 Nov 2011
Rediger Anne, Piechowski Carolin L, Yi Chun-Xia, Tarnow Patrick, Strotmann Rainer, Grüters Annette, Krude Heiko, Schöneberg Torsten, Tschöp Matthias H, Kleinau Gunnar, Biebermann Heike
Abstract excerpt
Interaction and cross-talk of G-protein-coupled receptors (GPCRs) are of considerable interest because an increasing number of examples implicate a profound functional and physiological relevance of homo- or hetero-oligomeric GPCRs. The ghrelin (growth hormone secretagogue receptor (GHSR)) and melanocortin-3 (MC3R) receptors are both known to have orexigenic effects on the hypothalamic control of body weight....
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