Article
Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction.
FEBS letters - 6 May 2011
Putula Jaana, Turunen Pauli M, Johansson Lisa, Näsman Johnny, Ra Runar, Korhonen Laura, Kukkonen Jyrki P
Abstract excerpt
We wanted to analyze the basis for the distinction between OX(1) and OX(2) orexin receptors by the known agonists, orexin-A, orexin-B and Ala(11), D-Leu(15)-orexin-B, of which the latter two show some selectivity for OX(2). For this, chimaeric OX(1)/OX(2) and OX(2)/OX(1) orexin receptors were generated. The receptors were transiently expressed in HEK-293 cells, and potencies of the agonists to elicit cytosolic...
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