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Article

DEC2 modulates orexin expression and regulates sleep.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2018

Hirano Arisa, Hsu Pei-Ken, Zhang Luoying, Xing Lijuan, McMahon Thomas, Yamazaki Maya, Ptáček Louis J, Fu Ying-Hui

Abstract excerpt

Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep regulation has been unclear. Here we report that prepro-orexin, also known as hypocretin (Hcrt), gene expression is...

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Share to Basic Helix-Loop-Helix Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 29531056
DOI: 10.1073/pnas.1801693115
PMCID: PMC5879715

Genes

BHLHE41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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