Article
Massively Parallel Sequencingof the Filaggrin Gene Reveals an Association Between FLG Loss-of-function Mutations and Leprosy.
Acta dermato-venereologica - 21 Oct 2020
Shi Wenhao, Mi Zihao, Wang Zhenzhen, Zhang Huimin, Wang Na, Wang Zhe, Zhang Bowen, Xia Qianqian, Yu Yueqian, Yu Gongqi, Sun Lele, Fu Xian, Wang Chuan, Liu Hong, Zhang Furen
Abstract excerpt
Filaggrin, encoded by the FLG gene, plays a crucial role in the barrier function of epidermis, but the association between FLG loss-of-function mutations and infectious skin diseases has not been systematically studied. FLG coding sequences from 945 patients with leprosy and 916 healthy controls were captured and enriched using an array-based high-throughput system, and subjected to next-generation sequencing....
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