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Article

Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs.

International journal of dermatology - 1 Dec 2016

Thomsen Simon Francis, Elmose Camilla, Szecsi Pal Bela, Stender Steen, Kyvik Kirsten Ohm, Backer Vibeke, Thyssen Jacob Pontoppidan

Abstract excerpt

OBJECTIVES: This study was designed to examine the association between loss-of-function mutations in the filaggrin gene (FLG) and atopic dermatitis (AD) and asthma in adult twins. METHODS: A previously well-characterized cohort of 575 adult twins were genotyped for the loss-of-function mutations in FLG (R501X, 2282del4 and R2447X) most common among northern Europeans. Subjects were examined for symptoms of atopic...

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Source

Identifiers

PMID: 27653621
DOI: 10.1111/ijd.13401

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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