Article
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum.
The Journal of allergy and clinical immunology - 1 Sept 2009
Gao Pei-Song, Rafaels Nicholas M, Hand Tracey, Murray Tanda, Boguniewicz Mark, Hata Tissa, Schneider Lynda, Hanifin Jon M, Gallo Richard L, Gao Li, Beaty Terri H, Beck Lisa A, Barnes Kathleen C, Leung Donald Y M
Abstract excerpt
BACKGROUND: Loss-of-function null mutations R501X and 2282del4 in the skin barrier gene, filaggrin (FLG), represent the most replicated genetic risk factors for atopic dermatitis (AD). Associations have not been reported in African ancestry populations. Atopic dermatitis eczema herpeticum (ADEH) is a rare but serious complication of AD resulting from disseminated cutaneous herpes simplex virus infections....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.