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Article

Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.

Molecular pharmacology - 1 Mar 2014

Dönmez Cakil Yaprak, Khunweeraphong Narakorn, Parveen Zahida, Schmid Diethart, Artaker Matthias, Ecker Gerhard F, Sitte Harald H, Pusch Oliver, Stockner Thomas, Chiba Peter

Abstract excerpt

The multispecific efflux transporter, P-glycoprotein, plays an important role in drug disposition. Substrate translocation occurs along the interface of its transmembrane domains. The rotational C2 symmetry of ATP-binding cassette transporters implies the existence of two symmetry-related sets of substrate-interacting amino acids. These sets are identical in homodimeric transporters, and remain evolutionary...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24366667
DOI: 10.1124/mol.113.088526
PMCID: PMC4503343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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