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Article

Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.

The Journal of biological chemistry - 12 Jul 2013

Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

The P-glycoprotein drug pump protects us from toxins. Drug-binding sites in the transmembrane (TM) domains (TMDs) are connected to the nucleotide-binding domains (NBDs) by intracellular helices (IHs). TMD-NBD cross-talk is a key step in the transport mechanism because drug binding stimulates ATP...

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Share to Adenosine Triphosphatases
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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Identifiers

PMID: 23733192
DOI: 10.1074/jbc.M113.484550
PMCID: PMC3711299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23733192-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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