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Article

Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity

17 Jun 2020

Abstract excerpt

P-glycoprotein (P-gp, ABCB1) overexpression is, currently, one of the most important multidrug resistance (MDR) mechanisms in tumor cells. Thus, modulating drug efflux by P-gp has become one of the most promising approaches to overcome MDR in cancer. Yet, more insights on the molecular basis of drug specificity and efflux-related signal transmission mechanism between the transmembrane domains (TMDs) and the...

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PMID: 32555203
DOI: 10.1038/s41598-020-66587-5

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