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Article

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Okamoto Toru, Coultas Leigh, Metcalf Donald, van Delft Mark F, Glaser Stefan P, Takiguchi Megumi, Strasser Andreas, Bouillet Philippe, Adams Jerry M, Huang David C S

Abstract excerpt

The B-cell CLL/lymphoma 2 (Bcl2) relative Myeloid cell leukemia sequence 1 (Mcl1) is essential for cell survival during development and for tissue homeostasis throughout life. Unlike Bcl2, Mcl1 turns over rapidly, but the physiological significance of its turnover has been unclear. We have gained insight into the roles of Mcl1 turnover in vivo by analyzing mice harboring a modified allele of Mcl1 that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

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Source

Open in PubMed Open full text

Identifiers

PMID: 24363325
DOI: 10.1073/pnas.1321259110
PMCID: PMC3890801

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.PMID 24363325Read ↗

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