Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

8 May 2014

Abstract excerpt

Mcl-1 is an anti-apoptotic protein of the Bcl-2 family that is essential for the survival of multiple cell lineages and that is highly amplified in human cancer. Under physiological conditions, Mcl-1 expression is tightly regulated at multiple levels, involving transcriptional, post-transcriptional and post-translational processes. Ubiquitination of Mcl-1, that targets it for proteasomal degradation, allows for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24814761
DOI: 10.3390/cells3020418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival ProteinPMID 24814761Read ↗

Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic optionsSemantic proximity Read ↗

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-SystemSemantic proximity Read ↗

Mcl‐1 targeting could be an intriguing perspective to cure cancerSemantic proximity Read ↗

Ubiquitin at the crossroad of cell death and survivalSemantic proximity Read ↗

A portrayal of E3 ubiquitin ligases and deubiquitylases in cancerSemantic proximity Read ↗

Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer ImmunotherapySemantic proximity Read ↗

Ubiquitin-independent degradation of antiapoptotic MCL-1.Semantic proximity Read ↗

The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 proteinSemantic proximity Read ↗

Mcl-1 Ubiquitination and DestructionSemantic proximity Read ↗

Programmed Death Ligand 1 Regulatory Crosstalk with Ubiquitination and Deubiquitination: Implications in Cancer ImmunotherapySemantic proximity Read ↗

The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting.Semantic proximity Read ↗

Ubiquitination in cancer: mechanisms and therapeutic opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.