Article
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
15 Apr 1993
Abstract excerpt
During their lifespan, immature cells normally pass through sequential transitions to a differentiated state and eventually undergo cell death. This progression is aberrant in cancer, although the transition to differentiation can be reestablished in inducible leukemia cell lines. This report describes a gene, MCL1, that we isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced...
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