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Article

Ubiquitin-independent degradation of antiapoptotic MCL-1.

Molecular and cellular biology - 1 Jun 2010

Stewart Daniel P, Koss Brian, Bathina Madhavi, Perciavalle Rhonda M, Bisanz Kristen, Opferman Joseph T

Abstract excerpt

Antiapoptotic myeloid cell leukemia 1 (MCL-1) is an essential modulator of survival during the development and maintenance of a variety of cell lineages. Its turnover, believed to be mediated by the ubiquitin-proteasome system, facilitates apoptosis induction in response to cellular stress. To investigate the contribution of ubiquitinylation in regulating murine MCL-1 turnover, we generated an MCL-1 mutant...

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Identifiers

PMID: 20385764
DOI: 10.1128/MCB.01266-09
PMCID: PMC2876674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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