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Article

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA.

Nature - 1 Jan 2000

Brill S J, DiNardo S, Voelkel-Meiman K, Sternglanz R

Abstract excerpt

Yeast strains with mutations in the genes for DNA topoisomerases I and II have been identified previously in both Saccharomyces cerevisiae and Schizosaccharomyces pombe. The topoisomerase II mutants (top2) are conditional-lethal temperature-sensitive (ts) mutants. They are defective in the termination of DNA replication and the segregation of daughter chromosomes, but otherwise appear to replicate and transcribe...

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PMID: 2436053
DOI: 10.1038/326414a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA.PMID 2436053Read ↗

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