Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.

doi:10.1093/genetics/141.2.465

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Article

Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.

Genetics - 1 Oct 1995

Sadoff B U, Heath-Pagliuso S, Castaño I B, Zhu Y, Kieff F S, Christman M F

Abstract excerpt

Despite evidence that DNA topoisomerase I is required to relieve torsional stress during DNA replication and transcription, yeast strains with a top1 null mutation are viable and display no gross defects in DNA or RNA synthesis, possibly because other proteins provide overlapping functions. We is...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Crosses, Genetic
DNA Replication
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
Genes, Fungal
Genes, Lethal
Genetic Complementation Test
Genotype
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Plasmids

Recombination, Genetic

Saccharomyces cerevisiae

Sequence Homology, Amino Acid

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8647385
DOI: 10.1093/genetics/141.2.465
PMCID: PMC1206748

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8647385-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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