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Article

Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.

Genetics - 1 Oct 1995

Sadoff B U, Heath-Pagliuso S, Castaño I B, Zhu Y, Kieff F S, Christman M F

Abstract excerpt

Despite evidence that DNA topoisomerase I is required to relieve torsional stress during DNA replication and transcription, yeast strains with a top1 null mutation are viable and display no gross defects in DNA or RNA synthesis, possibly because other proteins provide overlapping functions. We isolated mutants whose inviablility or growth defect is relieved when TOP1 is expressed [trf mutants (topoisomerase...

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Identifiers

PMID: 8647385
DOI: 10.1093/genetics/141.2.465
PMCID: PMC1206748

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.PMID 8647385Read ↗

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