Article
Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.
Annals of human genetics - 1 Jan 2014
Villegas Raquel, Williams Scott M, Gao Yu-Tang, Long Jirong, Shi Jiajun, Cai Hui, Li Honglan, Chen Ching-Chu, Tai E Shyong, Hu Frank, Cai Qiuyin, Zheng Wei, Shu Xiao-Ou
Abstract excerpt
We used a two-stage study design to evaluate whether variations in the peroxisome proliferator-activated receptors (PPAR) and the PPAR gamma co-activator 1 (PGC1) gene families (PPARA, PPARG, PPARD, PPARGC1A, and PPARGC1B) are associated with type 2 diabetes (T2D) risk. Stage I used data from a genome-wide association study (GWAS) from Shanghai, China (1019 T2D cases and 1709 controls) and from a meta-analysis of...
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