Article
Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population.
Diabetologia - 1 Jul 2005
Kim J H, Shin H D, Park B L, Cho Y M, Kim S Y, Lee H K, Park K S
Abstract excerpt
AIMS/HYPOTHESIS: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1alpha) is a transcriptional coactivator implicated in insulin release by beta cells and in insulin resistance. Therefore, genetic variation of PPARGC1A could be implicated in the onset of type 2 diabetes. In this study, we examined whether the PPARGC1A gene locus is associated with type 2 diabetes mellitus. We also...
Topics
- Age of Onset
- Aged
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Diabetes Mellitus, Type 2
- Genotype
- Heat-Shock Proteins
- Humans
- Korea
- Linkage Disequilibrium
- Middle Aged