Article
Genetic variants in peroxisome proliferator-activated receptor-γ and retinoid X receptor-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population.
Diabetes technology & therapeutics - 1 Feb 2011
Lu Ying, Ye Xinhua, Cao Yuanyuan, Li Qian, Yu Xiaofang, Cheng Jinluo, Gao Yanqin, Ma Jianhua, Du Wencong, Zhou Ling
Abstract excerpt
BACKGROUND: The serum levels of adiponectin are paradoxically decreased in obesity and may play important roles in the development of type 2 diabetes mellitus (T2DM). Potentially functional polymorphisms in the peroxisome proliferator-activated receptor-γ (PPAR-γ) and retinoid X receptor-α (RXR-α) genes may alter T2DM risks by increasing the human adiponectin promoter activity in cells. Therefore, we hypothesized...
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