Article
Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain HCV-RMT.
PloS one - 1 Jan 2013
Arai Masaaki, Tokunaga Yuko, Takagi Asako, Tobita Yoshimi, Hirata Yuichi, Ishida Yuji, Tateno Chise, Kohara Michinori
Abstract excerpt
Multiple genotype 1a clones have been reported, including the very first hepatitis C virus (HCV) clone called H77. The replication ability of some of these clones has been confirmed in vitro and in vivo, although this ability is somehow compromised. We now report a newly isolated genotype 1a clone, designated HCV-RMT, which has the ability to replicate efficiently in patients, chimeric mice with humanized liver,...
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