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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

9 Apr 2012

Abstract excerpt

Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid double-strand breaks (DSBs), mediated by the RNF8/RNF168 ubiquitin ligases, plays a key role in recruiting repair factors, including 53BP1 and BRCA1, to reestablish genome integrity. In this paper, we show that human RNF169, an uncharacterized E3 ubiquitin ligase paralogous to RNF168, accumulated in DSB repair foci through recognition of...

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PMID: 22492721
DOI: 10.1083/jcb.201109100

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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaksPMID 22492721Read ↗

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Molecular Insights into the Function of RING Finger (RNF)-containing Proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent UbiquitylationSemantic proximity Read ↗

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E3 ligases: a ubiquitous link between DNA repair, DNA replication and human diseaseSemantic proximity Read ↗

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage responseSemantic proximity Read ↗

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