Article
Tumor versus stromal cells in culture--survival of the fittest?
PloS one - 1 Jan 2013
Talasila Krishna M, Brekka Narve, Mangseth Kjersti, Stieber Daniel, Evensen Lasse, Rosland Gro V, Torsvik Anja, Wagner Marek, Niclou Simone P, Mahesparan Rupavathana, Vintermyr Olav K, Bjerkvig Rolf, Nigro Janice M, Miletic Hrvoje
Abstract excerpt
Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for example, occurs in 40 to 50% of GBM, and yet, EGFR amplification is rarely preserved in cell cultures derived from human tumors. To analyze the fate of EGFR amplified and IDH mutated cells in culture, we followed the development over...
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