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Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth

25 Mar 2024

Abstract excerpt

Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research tool useful for investigating the role of the human brain tumor microenvironment in glioblastoma. Here we describe long-term GLICOs, a novel model in which COs are grown from embryonic stem cell cultures containing low levels of GSCs and tumor development is monitored over extended durations...

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PMID: 38528608
DOI: 10.1186/s40478-024-01755-6

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