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Modelling glioblastoma tumour-host cell interactions using adult brain organotypic slice co-culture

1 Dec 2017

Abstract excerpt

ABSTRACT Glioblastoma multiforme (GBM) is an aggressive incurable brain cancer. The cells that fuel the growth of tumours resemble neural stem cells found in the developing and adult mammalian forebrain. These are referred to as glioma stem cells (GSCs). Similar to neural stem cells, GSCs exhibit a variety of phenotypic states: dormant, quiescent, proliferative and differentiating. How environmental cues within...

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PMID: 29196443
DOI: 10.1242/dmm.031435

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