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Article

Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules.

Neuro-oncology - 1 Dec 2013

Balvers Rutger K, Kleijn Anne, Kloezeman Jenneke J, French Pim J, Kremer Andreas, van den Bent Martin J, Dirven Clemens M F, Leenstra Sieger, Lamfers Martine L M

Abstract excerpt

BACKGROUND: Recent molecular characterization studies have identified clinically relevant molecular subtypes to coexist within the same histological entities of glioma. Comparative studies between serum-supplemented and serum-free (SF) culture conditions have demonstrated that SF conditions select for glioma stem-like cells, which superiorly conserve genomic alterations. However, neither the representation of...

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Identifiers

PMID: 24046260
DOI: 10.1093/neuonc/not116
PMCID: PMC3829587

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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