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Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency

27 Jun 2016

Abstract excerpt

Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence of a complex tumor microenvironment. Those factors are a key obstacle for the treatment of this tumor type. To model the disease in mice, the current strategy is to grow GBM cells in serum-free non-adherent condition, which maintains their tumor-initiating potential. However, the so-generated tumors are...

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PMID: 27345406
DOI: 10.1038/onc.2016.230

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