Pathogenic Th2-type follicular helper T cells contribute to the development of lupus in Fas-deficient mice.

Abstract excerpt

Fas mutant mice are well recognized as autoimmune mouse models, which develop symptoms similar to human systemic lupus erythematosus. Although disease severity in Fas mutant mice is greatly affected by the genetic background, the mechanisms affecting pathological heterogeneity among different strains of Fas mutant mice are poorly understood. In this study, we examined the phenotypic differences between...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoantibodies
• Share to B-Lymphocytes