Article
A genetic disorder of lymphocyte apoptosis involving the fas pathway: the autoimmune lymphoproliferative syndrome.
Current allergy and asthma reports - 1 Nov 2001
Fleisher T A, Straus S E, Bleesing J J
Abstract excerpt
Autoimmune lymphoproliferative syndrome (ALPS) is a recently characterized human disorder that typically presents with lymphocyte accumulation in the first few years of life. This is often associated with the development of autoimmunity, most commonly affecting the hematopoietic system. A key laboratory feature is the marked expansion of double-negative (CD4- and CD8-) T cells that express the alpha/beta T-cell...
Topics
- Apoptosis
- Autoimmune Diseases
- CD4 Antigens
- CD8 Antigens
- Heterozygote
- Homeostasis
- Humans
- Lymphoproliferative Disorders
- Mutation
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes
- fas Receptor