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Article

Systematic identification of immunodominant CD8 <sup>+</sup> T-cell responses to influenza A virus in HLA-A2 individuals

11 May 2011

Abstract excerpt

Immunodominant T-cell responses are important for virus clearance. However, the identification of immunodominant T-cell peptide + HLA glycoprotein epitopes has been hindered by the extent of HLA polymorphism and the limitations of predictive algorithms. A simple, systematic approach has been used here to screen for immunodominant CD8(+) T-cell specificities. The analysis targeted healthy HLA-A2(+) donors to allow...

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PMID: 21562214
DOI: 10.1073/pnas.1105624108

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